TGIF Inhibits Retinoid Signaling

Evaluation of Topramezone on Zebrafish Retinoid Signaling

Retinoid signaling alterations in amyotrophic lateral sclerosis.

Amyotrophic lateral sclerosis (ALS) is a fatal neuromuscular disease for which effective therapeutic interventions and an understanding of underlying disease mechanism are lacking. A variety of biochemical pathways are believed to contribute to the pathophysiology of ALS that are common to both sporadic and familial forms of the disease. Evidence from both human and animal studies indicates tha...

Retinoid signaling regulates primitive (yolk sac) hematopoiesis.

It is known from nutritional studies that vitamin A is an important factor for normal hematopoiesis, though it has been difficult to define its precise role. The vitamin A-deficient (VAD) quail embryo provides an effective ligand "knockout" model for investigating the function of retinoids during development. The VAD embryo develops with a significant reduction in erythroid cells, which has not...

Nuclear retention of the tumor suppressor cPML by the homeodomain protein TGIF restricts TGF-beta signaling.

The homeodomain protein TGIF has been implicated in the negative regulation of TGF-beta signaling. In this study, we report an unexpected role of TGIF in the inhibition of Smad2 phosphorylation, which occurs by a mechanism independent of its association with Smad2. This inhibitory function of TGIF is executed in concert with c-Jun, which facilitates the interaction of TGIF with cPML, resulting ...

Retinoid signaling acting through the nuclear retinoic acid

INTRODUCTION Retinoid signaling acting through the nuclear retinoic acid receptors (RARs) is crucial to the establishment of the anteroposterior (AP) axis during embryonic development. RARs function as ligand-modulated transcription factors that activate expression of their target genes (Chambon, 1996; Mangelsdorf et al., 1995; Mark et al., 2009). Studies in a variety of systems have shown that...