TGF-β/Smad signaling through DOCK4 facilitates lung adenocarcinoma metastasis
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چکیده
منابع مشابه
TGF-b/Smad signaling through DOCK4 facilitates lung adenocarcinoma metastasis
Jia-Ray Yu, Yilin Tai, Ying Jin, Molly C. Hammell, J. Erby Wilkinson, Jae-Seok Roe, Christopher R. Vakoc, and Linda Van Aelst Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA; Graduate Program in Genetics, Stony Brook University, Stony Brook, New York 11794, USA; Unit for Laboratory Animal Medicine, Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109...
متن کاملTGF-β/Smad signaling through DOCK4 facilitates lung adenocarcinoma metastasis.
The mechanisms by which TGF-β promotes lung adenocarcinoma (ADC) metastasis are largely unknown. Here, we report that in lung ADC cells, TGF-β potently induces expression of DOCK4, but not other DOCK family members, via the Smad pathway and that DOCK4 induction mediates TGF-β's prometastatic effects by enhancing tumor cell extravasation. TGF-β-induced DOCK4 stimulates lung ADC cell protrusion, ...
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purpose: to report a case of metastatic tumor to the right upper eyelid originating from a lung adenocarcinoma without any systemic signs. case report: a 68-year-old man had a two-month history of painless swelling in the right upper eyelid. the tumor slowly grew. two years before his presentation, he had received chemotherapy for lung cancer for one year. systemic and ocular examinations were ...
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Metastasis from lung adenocarcinoma can occur swiftly to multiple organs within months of diagnosis. The mechanisms that confer this rapid metastatic capacity to lung tumors are unknown. Activation of the canonical WNT/TCF pathway is identified here as a determinant of metastasis to brain and bone during lung adenocarcinoma progression. Gene expression signatures denoting WNT/TCF activation are...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2015
ISSN: 0890-9369,1549-5477
DOI: 10.1101/gad.248963.114