TGF-β1 and donor dendritic cells are common key components in donor-specific blood transfusion and anti-class II heart graft enhancement, whereas tolerance induction also required inflammatory cytokines down-regulation
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چکیده
منابع مشابه
CTLA4 signals are required to optimally induce allograft tolerance with combined donor-specific transfusion and anti-CD154 monoclonal antibody treatment.
Sensitization to donor Ags is an enormous problem in clinical transplantation. In an islet allograft model, presensitization of recipients through donor-specific transfusion (DST) 4 wk before transplantation results in accelerated rejection. We demonstrate that combined DST with anti-CD154 (CD40L) therapy not only prevents the deleterious presensitization produced by pretransplant DST in the is...
متن کاملInduction of Foxp3-Expressing Regulatory T-Cells by Donor Blood Transfusion Is Required for Tolerance to Rat Liver Allografts
BACKGROUND Donor-specific blood transfusion (DST) prior to solid organ transplantation has been shown to induce long-term allograft survival in the absence of immunosuppressive therapy. Although the mechanisms underlying DST-induced allograft tolerance are not well defined, there is evidence to suggest DST induces one or more populations of antigen-specific regulatory cells that suppress allogr...
متن کاملCritical requirement for graft passenger leukocytes in allograft tolerance induced by donor blood transfusion.
Tolerance to a vascularized allograft can be induced in adult animals by pregraft donor-specific blood transfusion (DST). Mechanisms underlying this effect appear to depend on unresponsiveness of alloreactive T-helper cells. In this study, we examined the roles of DST and cellular components of the allograft that are important in inducing T-cell unresponsiveness in a rat model. DST alone did no...
متن کاملRAPID COMMUNICATION Critical Requirement for Graft Passenger Leukocytes in Allograft Tolerance Induced by Donor Blood Transfusion
Tolerance to a vascularized allograft can be induced in adult animals by pregraft donor-specific blood transfusion (DST). Mechanisms underlying this effect appear to depend on unresponsiveness of alloreactive T-helper cells. In this study, we examined the roles of DST and cellular components of the allograft that are important in inducing T-cell unresponsiveness in a rat model. DST alone did no...
متن کاملLiver graft induced donor specific unresponsiveness without class I and/or class II antigen differences.
L IVER allografting induces specific systemic unresponsiveness to subsequent other donor tissues in pigs. l rats,2 and mice.3..Although the mechanism remains unclear, soluble donor crass I major histocompatibility complex (MHC) antigens and/or anti-donor class II alloantibodies have been proposed as critical components of the induced unresponsiveness.2.4.5 If those explanations are correct, a l...
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ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 2001
ISSN: 0014-2980,1521-4141
DOI: 10.1002/1521-4141(2001010)31:10<3111::aid-immu3111>3.0.co;2-6