Tetranucleotide GGGA Motif in Primary RNA Transcripts
نویسندگان
چکیده
منابع مشابه
Tetranucleotide GGGA Motif in Primary RNA Transcripts
Selecting effective antisense target sites on a given mRNA molecule constitutes a major problem in antisense therapeutics. By trial-and-error, only 1 in 18 (6%) of antisense oligonucleotides designed to target the primary RNA transcript of tumor necrosis factor-a (TNF-a) strongly inhibited TNF-a synthesis. Subsequent studies showed that the area in RNA targeted by antisense oligonucleotides cou...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1998
ISSN: 0021-9258
DOI: 10.1074/jbc.273.39.25125