Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia
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چکیده
منابع مشابه
Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia.
Ischemic stroke is the most common life-threatening neurological disease and has limited therapeutic options. One component of ischemic neuronal death is inflammation. Here we show that doxycycline and minocycline, which are broad-spectrum antibiotics and have antiinflammatory effects independent of their antimicrobial activity, protect hippocampal neurons against global ischemia in gerbils. Mi...
متن کاملP55: Neuroprotective and Neurogenesis Effects of Curcumin in the Adult Rat Brain Following Transient Global Ischemia
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متن کاملp55: neuroprotective and neurogenesis effects of curcumin in the adult rat brain following transient global ischemia
traumatic brain injury resulting road accidents create damage to the brain. the severe brain injury may cause extensive tissue loss of several parenchyma which results in cavities due to primary destruction and secondary injuries such as ischemia and inflammation. recent findings suggest that neuronal precursors in the adult mammalian brain can be a therapeutic target in ischemic brain injuries...
متن کاملEupatilin exerts neuroprotective effects in mice with transient focal cerebral ischemia by reducing microglial activation
Microglial activation and its-driven neuroinflammation are characteristic pathogenetic features of neurodiseases, including focal cerebral ischemia. The Artemisia asiatica (Asteraceae) extract and its active component, eupatilin, are well-known to reduce inflammatory responses. But the therapeutic potential of eupatilin against focal cerebral ischemia is not known, along with its anti-inflammat...
متن کاملNeuroprotective mechanism of (+)SKF 10,047 in vitro and in gerbil global brain ischemia.
BACKGROUND AND PURPOSE The N-methyl-D-aspartate receptor is believed to mediate part of the ischemic neuronal damage caused by the excitatory amino acid glutamate. (+)SKF 10,047, the prototypic sigma-agonist, interacts with the N-methyl-D-aspartate receptor. Therefore, we studied the neuroprotective effect of (+)SKF 10,047 on cultured rat cerebellar neurons and on CA1 hippocampal neurons of ger...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1998
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.95.26.15769