Tetrabromobisphenol A induced reproductive endocrine-disrupting effects in mussel Mytilus galloprovincialis

Tetrabromobisphenol A (TBBPA) pollution in marine environmental media poses great risks to organisms due its potential endocrine-disrupting effects. However, limited attention of TBBPA’s effects has been paid on invertebrates. In this work, the reproductive TBBPA were evaluated by observing gametes development, quantifying gender-specific gene expression, and determining vertebrate sex hormones mussels Mytilus galloprovincialis treated with for 30 days. Additionally, transcriptomic profiling enzymes activities conducted investigate mechanisms We found that promotion gametogenesis alterations occurred TBBPA-treated both sexes. Meanwhile, estrogen sulfotransferase (SULT1E1) steroid sulfatase (STS) up-regulated at transcript level as a result treatments, suggesting disrupted steroidogenesis through promoting steroids sulfonation hydrolysis sulfate steroids. The induction SULTs biotransformation might be responsible dysregulation metabolism. Overall, these findings provide new insight into assessing impact well biomonitoring environment. • exposure induced mussel. promoted altered levels SULT1E1 STS protein TBBPA. Steroids targets