Tethered Ligand Library for Discovery of Peptide Agonists
نویسندگان
چکیده
منابع مشابه
Design, synthesis, and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor.
Protease-activated receptors (PARs) represent a unique family of seven-transmembrane G protein-coupled receptors, which are enzymatically cleaved to expose a truncated extracellular N terminus that acts as a tethered activating ligand. PAR-1 is cleaved and activated by the serine protease alpha-thrombin, is expressed in various tissues (e.g., platelets and vascular cells), and is involved in ce...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1995
ISSN: 0021-9258
DOI: 10.1074/jbc.270.40.23398