Testosterone administration increases leukocyte-endothelium interactions and inflammation in transgender men
نویسندگان
چکیده
ObjectiveTo evaluate the effect of testosterone treatment on metabolic and inflammation parameters leukocyte-endothelium interactions in transgender men (TGM).DesignProspective observational study.SettingUniversity hospital.Patient(s)One hundred fifty-seven TGM.Intervention(s)Administration undecanoate (1,000 mg, intramuscular) every 12 weeks.Main Outcome Measure(s)Endocrine parameters, adhesion molecules (vascular cell molecule-1, intercellular E-selectin), proinflammatory cytokines interleukin-6, tumor necrosis factor alpha were evaluated serum before after using Luminex’s xMAP technology. In addition, between human umbilical vein endothelial cells polymorphonuclear leukocytes assessed by flow chamber microscopy.Result(s)Testosterone led to an increase due rolling decreased velocity. It also boosted levels vascular E-selectin, alpha. As expected, produced a significant free androgenic index, androstenedione, total testosterone, atherogenic index plasma decrease sex hormone–binding globulin high-density lipoprotein cholesterol.Conclusion(s)Treatment TGM with induces cytokines. These effects are reason monitor cardiovascular risk these patients. To (TGM). Prospective study. University hospital. One TGM. Administration weeks. Endocrine microscopy. Testosterone cholesterol. Treatment
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ژورنال
عنوان ژورنال: Fertility and Sterility
سال: 2021
ISSN: ['0015-0282', '1556-5653']
DOI: https://doi.org/10.1016/j.fertnstert.2020.08.002