منابع مشابه
Decellularized Tendon Extracellular Matrix—A Valuable Approach for Tendon Reconstruction?
Tendon healing is generally a time-consuming process and often leads to a functionally altered reparative tissue. Using degradable scaffolds for tendon reconstruction still remains a compromise in view of the required high mechanical strength of tendons. Regenerative approaches based on natural decellularized allo- or xenogenic tendon extracellular matrix (ECM) have recently started to attract ...
متن کاملMolecular interactions in extracellular matrix of tendon.
Tendon is a poorly vascularized and highly specialized connective tissue containing few scattered cells that play an important role in the musculoskeletal apparatus by resisting mechanical stress. Because of the slow rate of the metabolism of its molecular components, the tendon gradually loses its mechanical properties and may rupture upon an array of physical activities. In this report, we di...
متن کاملFunctional Characterization of Detergent-Decellularized Equine Tendon Extracellular Matrix for Tissue Engineering Applications
Natural extracellular matrix provides a number of distinct advantages for engineering replacement orthopedic tissue due to its intrinsic functional properties. The goal of this study was to optimize a biologically derived scaffold for tendon tissue engineering using equine flexor digitorum superficialis tendons. We investigated changes in scaffold composition and ultrastructure in response to s...
متن کاملTendon Extracellular Matrix Alterations in Ullrich Congenital Muscular Dystrophy
Collagen VI (COLVI) is a non-fibrillar collagen expressed in skeletal muscle and most connective tissues. Mutations in COLVI genes cause two major clinical forms, Bethlem myopathy and Ullrich congenital muscular dystrophy (UCMD). In addition to congenital muscle weakness, patients affected by COLVI myopathies show axial and proximal joint contractures and distal joint hypermobility, which sugge...
متن کاملExtracellular Matrix and Cytokines: A Functional Unit
The extracellular matrix (ECM) as well as soluble mediators like cytokines can influence the behavior of cells in very distinct as well as cooperative ways. One group of ECM molecules which shows an especially broad cooperativity with cytokines and growth factors are the proteoglycans. Proteoglycans can interact with their core proteins as well as their glycosaminoglycan chains with cytokines. ...
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ژورنال
عنوان ژورنال: Journal of Orthopaedic Research
سال: 2015
ISSN: 0736-0266
DOI: 10.1002/jor.22818