Temple syndrome in a patient with variably methylated CpGs at the primary MEG3/DLK1:IG-DMR and severely hypomethylated CpGs at the secondary MEG3:TSS-DMR

Methylation Status of H19/IGF2 Differentially Methylated Region in in vitro Human Blastocysts Donated by Healthy Couples

Backgrund: Imprinted genes are a unique subset of few genes, which have been differentially methylated region (DMR) in a parental origin-dependent manner during gametogenesis, and these genes are highly protected during pre-implantation epigenetic reprogramming. Several studies heve shown that the particular vulnerability of imprinting genes during suboptimal pre- and peri-conception microenvir...

Genotype-Epigenotype Interaction at the IGF2 DMR

Paternally expressed Insulin-like Growth Factor II (IGF2) encodes a gene whose protein product functions as a potent growth mitogen. Overexpression of IGF2 has been implicated in a wide number of disorders and diseases. IGF2 is regulated in part by differential methylation of the two parentally derived alleles. The differentially methylated region (DMR) located upstream of the imprinted promote...

Cobe-dmr-normalisation for Innationary at Dark Matter Models

The two-year C OBE-DMR 53 and 90 GHz sky maps, in both galactic and ecliptic coordinates, are used to determine the normalisation of innationary universe models with a at global geometry and adiabatic density perturbations. The appropriately normalised cold and mixed dark matter models and cosmological constant dominated, cold dark matter models, computed for a range of values of b and h, are t...

CPGS First Year Report

A Minimal Set of Tissue-Specific Hypomethylated CpGs Constitute Epigenetic Signatures of Developmental Programming

BACKGROUND Cell specific states of the chromatin are programmed during mammalian development. Dynamic DNA methylation across the developing embryo guides a program of repression, switching off genes in most cell types. Thus, the majority of the tissue specific differentially methylated sites (TS-DMS) must be un-methylated CpGs. METHODOLOGY AND PRINCIPAL FINDINGS Comparison of expanded Methyl ...