Temozolomide and oral etoposide in children with recurrent malignant brain tumors
نویسندگان
چکیده
منابع مشابه
High-dose chemotherapy with autologous stem cell rescue for children with recurrent malignant brain tumors.
BACKGROUND High-dose chemotherapy (HDCT) with autologous stem cell rescue (ASCR) has been reported to be effective in treating children with recurrent central nervous system (CNS) malignancies. METHODS To evaluate the efficacy and toxicities of HDCT and ASCR, the medical records of 27 children with recurrent CNS malignancies who received such therapy at St. Jude Children's Research Hospital b...
متن کاملA phase I study of cisplatin, temozolomide and thalidomide in patients with malignant brain tumors.
BACKGROUND There is pre-clinical evidence of synergism between cisplatin (P) and temozolomide (T) due to higher inhibition by T of O6-alkyl-guanine-alkyltransferase (AGAT), an enzyme involved in the mismatch repair system. T and P are active against malignant gliomas while thalidomide (TH) is emerging as an inhibitor of angiogenesis. PATIENTS AND METHODS Triplets of patients with malignant br...
متن کاملTemozolomide Chemotherapy in Patients with Recurrent Malignant Gliomas
Numerous studies have demonstrated the clinical activity of temozolomide, a second-generation alkylating agent, against malignant brain tumors, however, its activity has not been reported in an Asian population. This study analyzed the efficacy and toxicity of temozolomide in 25 adult patients with recurrent or progressive malignant gliomas after surgery and standard radiation therapy with or w...
متن کاملPilot study of vincristine, oral irinotecan, and temozolomide (VOIT regimen) combined with bevacizumab in pediatric patients with recurrent solid tumors or brain tumors.
BACKGROUND The combination of vincristine, oral irinotecan, and temozolomide (VOIT regimen) has shown antitumor activity in a pediatric Phase I trial. To further potentiate synergy, we assessed the safety and feasibility of adding bevacizumab to VOIT for children and young adults with recurrent tumors. METHODS Patients received vincristine (1.5 mg/m(2) on day 1), oral irinotecan (90 mg/m(2) o...
متن کاملAntiangiogenic metronomic therapy for children with recurrent embryonal brain tumors.
BACKGROUND Median survival time of recurrent embryonal brain tumors is short regardless of salvage chemotherapy used. An evolving alternative approach to conventional chemotherapy is to target neovascularization by interfering with tumor angiogenesis at various levels. PROCEDURE From November 2006 to December 2010, 16 patients (median age: 9 years) with recurrent (9 first, 7 multiple) embryon...
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ژورنال
عنوان ژورنال: Drugs in Context
سال: 2020
ISSN: 1740-4398
DOI: 10.7573/dic.2020-3-1