Telomeres: protecting chromosomes against genome instability
نویسندگان
چکیده
منابع مشابه
Cost-benefit of muscle cocontraction in protecting against spinal instability.
STUDY DESIGN Lifting dynamics and electromyographic activity were evaluated using a biomechanical model of spinal equilibrium and stability to assess cost-benefit effects of antagonistic muscle cocontraction on the risk of stability failure. OBJECTIVES To evaluate whether increased biomechanical stability associated with antagonistic cocontraction was capable of stabilizing the related increa...
متن کاملTelomeres, chromosome instability and cancer
Telomeres are composed of repetitive G-rich sequence and an abundance of associated proteins that together form a dynamic cap that protects chromosome ends and allows them to be distinguished from deleterious DSBs. Telomere-associated proteins also function to regulate telomerase, the ribonucleoprtotein responsible for addition of the species-specific terminal repeat sequence. Loss of telomere ...
متن کاملSegmenting telomeres and chromosomes in cells
The very end of every chromosome is a region called the telomere. Telomeres are nucleo-protein complexes containing specific DNA repeat sequences whose lengths are strongly believed to give indications to aging and tumor progression. In order to study the role these repeat sequences play in the cell, we developed a fluorescence microscopy imaging system and associated image analysis methods to ...
متن کاملPeroxiredoxin Tsa1 Is the Key Peroxidase Suppressing Genome Instability and Protecting against Cell Death in Saccharomyces cerevisiae
Peroxiredoxins (Prxs) constitute a family of thiol-specific peroxidases that utilize cysteine (Cys) as the primary site of oxidation during the reduction of peroxides. To gain more insight into the physiological role of the five Prxs in budding yeast Saccharomyces cerevisiae, we performed a comparative study and found that Tsa1 was distinguished from the other Prxs in that by itself it played a...
متن کاملGenomic Instability in Newborn with Short Telomeres
UNLABELLED Telomere length is considered to be a risk factor in adults due to its proved association with cancer incidence and mortality. Since newborn present a wide interindividual variation in mean telomere length, it is relevant to demonstrate if these differences in length can act also as an early risk indicator. To answer this question, we have measured the mean telomere length of 74 samp...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2010
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm2848