منابع مشابه
Anchored telomeres get longer
T wo groups conclude that factors near telomeres alter the telomeres' nuclear positioning and thus their length. The lengths of telomeres, which are caps for chromosome ends, are kept consistent by a pathway that " counts " the number of Rap1 molecules bound to telomeres. This pathway signals through Tel1 to recruit the lengthening telomerase enzyme. Cells missing Tel1 have shorter but stable t...
متن کاملALT Telomeres Get Together with Nuclear Receptors
Nuclear receptors bind chromosome ends in "alternative lengthening of telomeres" (ALT) cancer cells that maintain their ends by homologous recombination instead of telomerase. Marzec et al. now demonstrate that, in ALT cells, nuclear receptors not only trigger distal chromatin associations to mediate telomere-telomere recombination events, but also drive chromosome-internal targeted telomere in...
متن کاملALT Telomeres Borrow from Meiosis to Get Moving
Telomere clustering is required for the homologous recombination events that maintain chromosome ends in cells relying on alternative lengthening of telomeres (ALT). New data demonstrate that damage signaling at telomeres, a likely step in activating maintenance mechanisms, induces directional movement and synapsis driven by the machinery responsible for recombination in meiosis.
متن کاملPPARγ: no SirT, no service.
A novel mechanism has been defined for controlling per-oxisome proliferator-activated receptors γ (PPARγ) activity in response to thiazolidinedione (TZD) ligands, in which deacetylation of PPARγ by SirT1 remodels the transcriptional complex. This change favors expression of genes associated with increased energy use and insulin sensitization in white adipose tissue (WAT), and is required for a ...
متن کاملTelomeres
What are they? Telomeres are the natural tips of chromosomes. They consist of tandem arrays of simple G-rich repetitive DNA sequences that are complexed with proteins. The fundamental tools for keeping telomeres healthy are amazingly similar in both single cell eukaryotes, such as yeast and ciliated protozoa, and human cells. What do they do? Telomeres have two important duties. First, they are...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2010
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1917iti2