Telomere Length Is Predictive of Breast Cancer Risk in BRCA2 Mutation Carriers
نویسندگان
چکیده
منابع مشابه
Lymphocyte telomere length is long in BRCA1 and BRCA2 mutation carriers regardless of cancer-affected status.
BACKGROUND Telomere length has been linked to risk of common diseases, including cancer, and has previously been proposed as a biomarker for cancer risk. Germline BRCA1 and BRCA2 mutations predispose to breast, ovarian, and other cancer types. METHODS We investigated telomere length in BRCA mutation carriers and their non-carrier relatives and further examined whether telomere length is a mod...
متن کاملBreast cancer risk among male BRCA1 and BRCA2 mutation carriers.
Men who carry germline mutations in the BRCA2 gene have a higher risk of developing breast carcinoma than men in the general population. Men who carry germline mutations in the BRCA1 gene may also be at a higher risk for breast carcinoma, but this association is not as well established. We evaluated the risks of developing breast carcinoma for male BRCA1 and BRCA2 mutation carriers in the US po...
متن کاملRe: Oral contraceptives and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers.
In a recent issue of the Journal, Narod et al. (1) reported findings from a large sample of 2611 BRCA1 and BRCA2 germline mutation carriers regarding the association of oral contraceptive use with the risk of breast cancer. An interesting feature of this report— not commented on by the authors—is data regarding cigarette smoking. The proportion of breast cancer case subjects who ever smoked was...
متن کاملOophorectomy after menopause and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers.
BACKGROUND To evaluate the effect of the cumulative number of ovulatory cycles and its contributing components on the risk of breast cancer among BRCA mutation carriers. METHODS We conducted a matched case-control study on 2,854 pairs of women with a BRCA1 or BRCA2 mutation. Conditional logistic regression was used to estimate the association between the number of ovulatory cycles and various...
متن کاملOral contraceptives and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers.
BACKGROUND Oral contraceptive use has been associated with an increase in the risk of breast cancer in young women. We examined whether this association is seen in women at high risk of breast cancer because they carry a mutation in one of two breast cancer susceptibility genes, BRCA1 and BRCA2. METHODS We performed a matched case-control study on 1311 pairs of women with known deleterious BR...
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ژورنال
عنوان ژورنال: Cancer Epidemiology Biomarkers & Prevention
سال: 2017
ISSN: 1055-9965,1538-7755
DOI: 10.1158/1055-9965.epi-16-0946