TEAD family transcription factors in development and disease

ABSTRACT The balance between stem cell potency and lineage specification entails the integration of both extrinsic intrinsic cues, which ultimately influence gene expression through activity transcription factors. One example this is provided by Hippo signalling pathway, plays a central role in regulating organ size during development. pathway mediated transcriptional co-factors Yes-associated protein (YAP) co-activator with PDZ-binding motif (TAZ), interact TEA domain (TEAD) proteins to regulate expression. Although roles YAP TAZ have been intensively studied, played TEAD are less well understood. Recent studies begun address this, revealing that TEADs progenitor self-renewal differentiation throughout various stages Furthermore, it becoming apparent other biology. This Primer provides an overview development, focusing on their as within developmental, homeostatic disease contexts.