Teaching Video NeuroImages: Cerebral amyloid angiopathy-related transient focal neurologic episodes

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Cerebral amyloid angiopathy and transient focal neurological episodes.

next most common clinical presentation of CAA after ICH. TFNEs were recurrent, stereotyped, brief (usually <30 min) but had a very wide clinical spectrum: although about half were positive (‘auralike’) spreading somatosensory or visual symptoms, the other half were predominantly negative symptoms, resembling ‘classic’ TIAs (e.g. hemiparesis or dysphasia), in keeping with the observations by Pat...

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Teaching NeuroImages: Cerebral amyloid angiopathy-related inflammation presenting with isolated leptomeningitis.

A 69-year-old woman presented with 1 month of rapid cognitive decline preceded by 1 year of very mild memory changes. Examination showed impaired attention, logopenic aphasia, anosognosia, simultagnosia, graphesthesia, and apraxia. Neuroimaging demonstrated leptomeningeal enhancement without significant parenchymal lesions or cerebral microbleeds (figure 1). A lymphocytic pleocytosis (15 nuclea...

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Spectrum of transient focal neurological episodes in cerebral amyloid angiopathy: multicentre magnetic resonance imaging cohort study and meta-analysis.

BACKGROUND AND PURPOSE Transient focal neurological episodes (TFNE) are recognized in cerebral amyloid angiopathy (CAA) and may herald a high risk of intracerebral hemorrhage (ICH). We aimed to determine their prevalence, clinical neuroimaging spectrum, and future ICH risk. METHODS This was a multicenter retrospective cohort study of 172 CAA patients. Clinical, imaging, and follow-up data wer...

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Imaging Findings of Cerebral Amyloid Angiopathy, Aβ-Related Angiitis (ABRA), and Cerebral Amyloid Angiopathy–Related Inflammation

Vascular inflammation is present in a subset of patients with cerebral amyloid angiopathy (CAA) and has a major influence in determining the disease manifestations. Radiological characterization of this subset is particularly important to achieve early recognition and treatment. We conducted this study to investigate the role of imaging in differentiating CAA with and without inflammation. We r...

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Mystery case: cerebral amyloid angiopathy-related inflammation.

A 59-year-old man was arrested for unruly public behavior. He was subsequently found unresponsive with bilateral upper extremity extensor posturing and lower extremity triple flexion when stimulated. Over the next 48 hours, he awoke and became belligerent. MRI revealed innumerable cortical microhemorrhages on susceptibility-weighted imaging (figure, A) and asymmetric subcortical T2 hyperintensi...

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ژورنال

عنوان ژورنال: Neurology

سال: 2018

ISSN: 0028-3878,1526-632X

DOI: 10.1212/wnl.0000000000006555