TEA BIOACTIVE COMPOUNDS AS INHIBITOR OF MRSA PENICILLIN BINDING PROTEIN 2a (PBP2a): A MOLECULAR DOCKING STUDY
نویسندگان
چکیده
ABSTRACT Methicillin-Resistant Staphylococcus aureus (MRSA) is a hypervirulent multidrug- resistant bacteria. It spreading around the globe and starting to be global health problem. causes bacteremia, infective endocarditis, bloodstream infection. PBP2a protein responsible for MRSA’s resistance antibiotics, especially beta-lactams. Tea contains bioactive compounds such as polyphenols. known have great antibacterial activities. Therefore, this study aims find potentials from tea polyphenols that can inhibit in MRSA with better binding energy than currently available drugs using molecular docking approach. We found theaflavin (-9,7 kcal/mol), one of compound, has ceftaroline (9,5 kcal/mol) therefore predicted activity. (−)- Epigallocatechingallate (-9,1 (−)-epicatechingallate (-8,8 myricetin (- 8,7 quercetin (-8,5 (−)-epicatechin (-8,3 epigallocatechin kaempferol procyanidin B2 (-8,1), theflavindigallate (-7,6 also potential due its low energy. Key words : Molecular docking, MRSA, PBP2a,
منابع مشابه
Inhibition of penicillin-binding protein 2a (PBP2a) in methicillin resistant Staphylococcus aureus (MRSA) by combination of ampicillin and a bioactive fraction from Duabanga grandiflora
BACKGROUND The inhibition of penicillin-binding protein 2a (PBP2a) is a promising solution in overcoming resistance of methicillin resistance Staphylococcus aureus (MRSA). A potential approach in achieving this is by combining natural product with currently available antibiotics to restore the activity as well as to amplify the therapeutic ability of the drugs. We studied inhibition effects of ...
متن کاملAuthor's response to reviews Title:Inhibition of penicillin-binding protein 2a (PBP2a) in methicillin resistant Staphylococcus aureus (MRSA) by combination of ampicillin and a bioactive fraction from Duabanga grandiflora
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ژورنال
عنوان ژورنال: Jurnal Farmasi Medica
سال: 2021
ISSN: ['2622-9463', '2654-640X']
DOI: https://doi.org/10.35799/pmj.3.2.2020.32878