TCR hypervariable regions expressed by T cells that respond to effective tumor vaccines

Correction for “ Peptide vaccines prevent tumor growth by acti - vating T cells that respond to native tumor antigens , ” by Kimberly

IMMUNOLOGY Correction for “Peptide vaccines prevent tumor growth by activating T cells that respond to native tumor antigens,” by Kimberly R. Jordan, Rachel H. McMahan, Charles B. Kemmler, John W. Kappler, and Jill E. Slansky, which appeared in issue 10, March 9, 2010, of Proc Natl Acad Sci USA (107:4652–4657; first published January 26, 2010; 10.1073/pnas.0914879107). The authors note that due...

Preferential recognition of TCR hypervariable regions by human anti-idiotypic T cells induced by T cell vaccination.

T cell responses to myelin basic protein (MBP) are potentially involved in the pathogenesis of multiple sclerosis (MS). Immunization with irradiated MBP-reactive T cells (T cell vaccination) induces anti-idiotypic T cell responses that suppress circulating MBP-reactive T cells. This T cell-T cell interaction is thought to involve the recognition of TCR expressed on target T cells. The study was...

T cells that cannot respond to TGF-β escape control by CD4+CD25+ regulatory T cells

CD4(+)CD25(+) regulatory T (T reg) cells play a pivotal role in control of the immune response. Transforming growth factor-beta (TGF-beta) has been shown to be required for T reg cell activity; however, precisely how it is involved in the mechanism of suppression is poorly understood. Using the T cell transfer model of colitis, we show here that CD4(+)CD45RB(high) T cells that express a dominan...

Vaccines for Active Immunotherapy of T Cell Are More Effective Than TCR Id Protein Tumor Cell Lysate-Pulsed Dendritic Cells

Requirements for effective antitumor responses of TCR transduced T cells.

Adoptive transfer of TCR gene-modified T cells has been proposed as an attractive approach to target tumors for which it is difficult or impossible to induce strong tumor-specific T cell responses by vaccination. Whereas the feasibility of generating tumor Ag-specific T cells by gene transfer has been demonstrated, the factors that determine the in vivo effectiveness of TCR-modified T cells are...