TCF7L2 rs7903146 variant does not associate with smallness for gestational age in the French population
نویسندگان
چکیده
منابع مشابه
Attention problems in relation to gestational age at birth and smallness for gestational age.
BACKGROUND While it is well established that very preterm birth (gestational age at birth <32 weeks) is related to increased attention problems, there is still considerable uncertainty of the effects of moderate or late preterm birth or smallness for gestational age (SGA) on attention regulation. AIMS To investigate the impact of gestational age at birth and SGA, birth on child attention prob...
متن کاملReplication of TCF7L2 rs7903146 association with type 2 diabetes in an Iranian population
The transcription factor 7-like 2 gene (TCF7L2) rs7903146 T allele is constantly associated with Type 2 diabetes in various populations and ethnic groups. Nevertheless, this has not been observed in two studies involving Arab populations. The aim of the present study was to investigate the association between TCF7L2 rs7903146 in an Iranian population. Type 2 diabetes patients (N = 258) and norm...
متن کاملTCF7L2 Variant rs7903146 Affects the Risk of Type 2 Diabetes by Modulating Incretin Action
OBJECTIVE Common variants in the gene TCF7L2 confer the largest effect on the risk of type 2 diabetes. The present study was undertaken to increase our understanding of the mechanisms by which this gene affects type 2 diabetes risk. RESEARCH DESIGN AND METHODS Eight subjects with risk-conferring TCF7L2 genotypes (TT or TC at rs7903146) and 10 matched subjects with wild-type genotype (CC) unde...
متن کاملDefining Smallness for Gestational Age in the Early Years of the Danish Medical Birth Registry
BACKGROUND Being born small for gestational age (SGA) is associated with decreased insulin sensitivity and increased blood pressure in childhood, but the association with clinical disease in early adulthood is less certain. The Danish Medical Birth Registry has registered all births in Denmark since 1973, but due to variable data quality, data is most often used only from 1981 onwards, and birt...
متن کاملTCF7L2 variants associate with CKD progression and renal function in population-based cohorts.
Genetic variants may increase susceptibility to both diabetes and kidney disease. Whether known diabetes-associated variants in the transcription factor 7-like 2 (TCF7L2) gene are associated with chronic kidney disease (CKD) progression and markers of kidney function is unknown. Participants of the Atherosclerosis Risk in Communities Study (ARIC; n = 11,061 self-identified white and n = 4014 bl...
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ژورنال
عنوان ژورنال: BMC Medical Genetics
سال: 2007
ISSN: 1471-2350
DOI: 10.1186/1471-2350-8-37