Tbx1 and Brn4 regulate retinoic acid metabolic genes during cochlear morphogenesis
نویسندگان
چکیده
منابع مشابه
DiGeorge syndrome, Tbx1, and retinoic acid signaling come full circle.
Among the most well-characterized cardiac congenital malformations are those associated with DiGeorge syndrome (DGS)/velocardiofacial syndrome. DGS is mainly caused by heterozygous deletion of a region of chromosome 22q11.2 and is characterized by cardiac conotruncal malformations, aortic arch anomalies, dysmorphic face and hypoplasia of the thymus and parathyroid.1 This spectrum of anomalies i...
متن کاملRegulation of retinoic acid signaling during lung morphogenesis.
Little is known about how retinoic acid (RA) synthesis, utilization and metabolism are regulated in the embryonic lung and how these activities relate to lung pattern formation. Here we report that early lung bud formation and subsequent branching morphogenesis are characterized by distinct stages of RA signaling. At the onset of lung development RA signaling is ubiquitously activated in primar...
متن کاملTBX1 is required for inner ear morphogenesis.
TBX1 is thought to be a critical gene in the pathogenesis of del22q11/DiGeorge syndrome (DGS). Morphological abnormalities of the external ear and hearing impairment (conductive or sensorineural) affect the majority of patients. Here we show that homozygous mutation of the mouse homolog Tbx1 is associated with severe inner ear defects that prevent the formation of the cochlea and of the vestibu...
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Retinoic acid (RA) displays pronounced anticarcinogenic activities in several types of cancer. Whereas the mechanisms that underlie this activity remain incompletely understood, tumor suppression by RA is believed to emanate primarily from its ability to regulate transcription of multiple target genes. Here, we investigated molecular events through which RA inhibits the growth of MCF-7 mammary ...
متن کاملRetinoic acid signalling during development.
Retinoic acid (RA) is a vitamin A-derived, non-peptidic, small lipophilic molecule that acts as ligand for nuclear RA receptors (RARs), converting them from transcriptional repressors to activators. The distribution and levels of RA in embryonic tissues are tightly controlled by regulated synthesis through the action of specific retinol and retinaldehyde dehydrogenases and by degradation via sp...
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ژورنال
عنوان ژورنال: BMC Developmental Biology
سال: 2009
ISSN: 1471-213X
DOI: 10.1186/1471-213x-9-31