Taxanes: vesicants, irritants, or just irritating?

Administering vesicants.

01. A vesicant is defi ned as an agent that has the potential to cause a. Blistering, severe tissue injury, or tissue necrosis. b. A palpable cord along a vein. c. Immediate streaking along a vein. d. Aching and tightness along a vein. 02. Which of the following are vesicants in the “ABVD” chemotherapy protocol? More than one response may be correct. a. Doxorubicin b. Bleomycin c. Vinblastine d...

Chapter 8 VESICANTS

Chapter 7 VESICANTS

Pulpal irritants

The dental pulp is characterized as a connective tissue and as such it is not considered an external tissue, yet its exposure to external stimuli is constant. This is due to a number of factors including the permeability of attrited or disrupted enamel as well as that of physiologic dentin and cementum. The pulp is extraordinarily sensitive to its external environment. Once thought to be a vest...

Ixabepilone in metastatic breast cancer: complement or alternative to taxanes?

SCCRO (DCUN1D1) Induces Extracellular Matrix Invasion by Activating Matrix Metalloproteinase 2. Pornchai O-charoenrat, Inderpal Sarkaria, Simon G. Talbot, Pabbathi Reddy, Su Dao, Ivan Ngai, Ashok Shaha, Dennis Kraus, Jatin Shah, Valerie Rusch, Y. Ramanathan, and Bhuvanesh Singh..........................................................................................................................