Taurine Antioxidant Effect in Decreasing Kidney Damage in Male Mice (Mus Musculus) due to Oxidative Stress Induced by Paraquat

Paraquat toxicity occurs through the high production of reactive oxygen species (ROS) which cause damage due to oxidative stress. Antioxidants can reduce prevention Taurine has shown ability act as an antioxidant. The aim this research is find a effect antioxidant taurine decrease kidney caused by stress paraquat looking at histopathology changes. 25 male adult mices from strain DDY were used and divided into five treatment groups; C(-) (Aquadest IP), C(+) (Paraquat 30mg/kg), P1 30mg/kg + 250mg/kg), P2 500mg/kg) P3 1000mg/kg). All groups given intraperitoneal for twenty one days. sacrificed where collected preparation. parameters measured renal histopathological changes in form degeneration necrosis. results show that administration had on decreased degrees tubular cells, with mean degree Degeneration cells (P2) reduced compared group (C+) there significant differences (P <0.05). Necrosis (P1, P2) In conclusion, proves causes are characterized It also dose 500 mg/kgBB could provided optimal effect.