Tau protein liquid–liquid phase separation can initiate tau aggregation
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چکیده
منابع مشابه
Tau protein liquid–liquid phase separation can initiate tau aggregation
The transition between soluble intrinsically disordered tau protein and aggregated tau in neurofibrillary tangles in Alzheimer's disease is unknown. Here, we propose that soluble tau species can undergo liquid-liquid phase separation (LLPS) under cellular conditions and that phase-separated tau droplets can serve as an intermediate toward tau aggregate formation. We demonstrate that phosphoryla...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2018
ISSN: 0261-4189,1460-2075
DOI: 10.15252/embj.201798049