Tau acetylates and stabilizes β‐catenin thereby promoting cell survival
نویسندگان
چکیده
منابع مشابه
CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival.
The microtubule-binding protein tau has been implicated in the neurofibrillary pathology of Alzheimer's disease. Within affected cells, ubiquitinated and hyperphosphorylated tau assembles into massive filamentous polymers. Eventually these tangle-bearing neurons die. The formation of neurofibrillary tangles closely parallels the progression and anatomic distribution of neuronal loss in Alzheime...
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ژورنال
عنوان ژورنال: EMBO reports
سال: 2020
ISSN: 1469-221X,1469-3178
DOI: 10.15252/embr.201948328