Targeting wingless-integrated/β-catenin (Wnt/β-catenin) signaling pathway as a new therapeutic modality

Wingless-integrated/β-catenin (Wnt/β-catenin) signaling pathway is an evolutionarily conserved which not only important for regulation of embryogenesis and organ development, but also injury repair, homeostasis tissue remodeling. Dysregulation this either by upregulation or even downregulation highly implicated in various diseases such as; liver diseases, kidney lung fibrosis, heart failure, vascular calcification, osteoporosis, cellular senescence, neurodegeneration, Alzheimer's disease cancers. Thus, targeting Wnt/β-catenin has attracted scientific research as a good strategy ameliorating several diseases.  In review we discussed components, the Wnt-on state Wnt-off state. Furthermore, summarized effects distinct organs including brain, bone, liver, heart, kidney. We molecules that act modulators via its components (Wnt, Frizzled, LRP5/6, Porcupine, Disheveled, β-catenin destruction complex activity) aiming to show their possible therapeutic potential diseases.