منابع مشابه
Targeting the chemokines in myocardial inflammation.
The chemokines comprise a large family of small, highly basic proteins that play a critical role in basal and inflammatory leukocyte locomotion and trafficking.1,2 In addition to effects on cell locomotion, certain chemokines are capable of eliciting a variety of other responses affecting leukocyte adhesion, activation, and degranulation, mitogenesis, and apoptosis. Furthermore, chemokines have...
متن کاملChemokines and cardiac fibrosis.
Several members of the chemokine family play an important role in reparative fibrosis and are involved in the pathogenesis of remodeling following myocardial infarction. Chemokines may regulate the fibrotic process through recruitment and activation of mononuclear cell subsets and fibroblast progenitors (fibrocytes), by exerting direct effects on resident fibroblasts, and by modulating angiogen...
متن کاملPotential Role of Chemokines in Fracture Repair
Chemokines are a family of small cytokines that share a typical key structure that is stabilized by disulfide bonds between the cysteine residues at the NH2-terminal of the protein, and they are secreted by a great variety of cells in several different conditions. Their function is directly dependent on their interactions with their receptors. Chemokines are involved in cell maturation and diff...
متن کاملcoxsackievirus b3 infection induced viral myocarditis by regulating the expression pattern of chemokines in cardiac myocytes
viral myocarditis is a common cardiovascular disease, which has greatly threatened human health. however, up to now, the pathogenesis of viral myocarditis has been unclear, which leads to the lack of its effective treatments. to investigate the role of chemokines in pathogenesis of viral myocarditis, mrna expression for a panel of 19 chemokines detected by rt-pcr in myocardial tissue of balb/c ...
متن کاملThe role of chemokines and chemokine receptors in mycosis fungoides
Background: Chemokines are a family of cytokines initially characterized by their capacity to induce chemotaxis, or directed leukocyte migrations. These receptors are activated by chemotactic cytokines called chemokines. Interactions between chemokines and chemokine receptors also are involved in tumorigenesis, migration and invasion of lymphoma cells.Methods: An English literature search...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Pharmaceutical Design
سال: 2014
ISSN: 1381-6128
DOI: 10.2174/13816128113199990449