Targeting TB persistence

Glycomimetic inhibitors of mycobacterial glycosyltransferases: targeting the TB cell wall.

Tuberculosis (TB) is the cause of more than a million deaths a year and is believed to infect a third of the world’s population. Emergent multidrug-resistant strains of Mycobacterium tuberculosis, the organism that causes the disease, and difficulties in treating immunocompromised individuals have further increased the urgency of the threat. The cell wall of mycobacteria is formed by polysaccha...

Targeting Bacterial Persistence to Develop Therapeutics Against Infectious Disease

Inflation Targeting and Regional Inflation Persistence: Evidence from Korea

The adoption of a credible monetary policy regime such as inflation targeting is known to reduce the persistence of inflation fluctuations. This conclusion, however, is derived from aggregate inflation or sectoral inflation rates, not from regional inflation data. This paper studies the regional dimension of inflation targeting, i.e. the consequences of inflation targeting for regional inflatio...

Targeting Mediators of Smoking Persistence with Intranasal Insulin

Rapid-acting, non-irritating nasal treatment options for smoking cessation pharmacotherapy are lacking. The halt in development is due, in part, to difficulty in delivering compounds across the blood brain barrier. Recently, in both human and animal models, insulin was shown to be capable of being transported to the cerebrospinal fluid and various brain regions via the "nose-to-brain" pathway, ...

Persistence of disease in territorial animals: insights from spatial models of Tb

Early models of directly transmitted wildlife disease focused on rabies transmission as a travelling wave, usually in a homogeneous density of wildlife. Such models of epi-enzootic diseases paid little attention to local-scale disease prevalence. Historical data on bovine tuberculosis (Tb) in cattle indicates that very localised areas can suffer from frequent repeat breakdowns, indicating that ...