Targeting reactive nitrogen species suppresses hereditary pancreatic cancer
نویسندگان
چکیده
منابع مشابه
Targeting reactive nitrogen species suppresses hereditary pancreatic cancer.
Germline mutation of BRCA2 induces hereditary pancreatic cancer. However, how BRCA2 mutation specifically induces pancreatic tumorigenesis remains elusive. Here, we have examined a mouse model of Brca2-deficiency-induced pancreatic tumors and found that excessive reactive nitrogen species (RNS), such as nitrite, are generated in precancerous pancreases, which induce massive DNA damage, includin...
متن کاملCorrection for Li et al., Targeting reactive nitrogen species suppresses hereditary pancreatic cancer.
MEDICAL SCIENCES Correction for “Targeting reactive nitrogen species suppresses hereditary pancreatic cancer,” by Mo Li, Qian Chen, Teng Ma, and Xiaochun Yu, which was first published June 19, 2017; 10.1073/pnas.1702156114 (Proc Natl Acad Sci USA 114: 7106–7111). The authors note that the author contributions footnote appeared incorrectly. Xiaochun Yu should be credited with designing research,...
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The plasma jet has been proposed as a novel therapeutic method for cancer. Anticancer activity of plasma has been reported to involve mitochondrial dysfunction. However, what constituents generated by plasma is linked to this anticancer process and its mechanism of action remain unclear. Here, we report that the therapeutic effects of air plasma result from generation of reactive oxygen/nitroge...
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Reactive oxygen species (ROS) play key roles in many pathogenic processes, including carcinogenesis, inflammation, ischemia-reperfusion injury and signal transduction. Also, reactive nitrogen species (RNS) cause various biological events such as neurodegenerative disorders. Sensitive and specific detection methods for ROS and RNS in biological samples should be useful for elucidation of biologi...
متن کاملModulation of reactive oxygen species in pancreatic cancer.
PURPOSE The aim of the present study was to compare the effects of the three different forms of the antioxidant enzyme superoxide dismutase [i.e., manganese superoxide dismutase (MnSOD), copper zinc superoxide dismutase (CuZnSOD), and extracellular superoxide dismutase (EcSOD)] on the malignant phenotype of human pancreatic cancer. EXPERIMENTAL DESIGN Human pancreatic cancer cell lines were i...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2017
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1702156114