Targeting Radiotherapy to Cancer by Gene Transfer
نویسندگان
چکیده
منابع مشابه
Targeting Radiotherapy to Cancer by Gene Transfer
Targeted radionuclide therapy is an alternative method of radiation treatment which uses a tumor-seeking agent carrying a radioactive atom to deposits of tumor, wherever in the body they may be located. Recent experimental data signifies promise for the amalgamation of gene transfer with radionuclide targeting. This review encompasses aspects of the integration of gene manipulation and targeted...
متن کاملTargeting Cardiac Myocytes by Gene Transfer
among the earliest in the field, and more recently gene and cell therapies have demonstrated significant potential for the treatment of common cardiovascular problems such as refractory myocardial ischaemia and dysfunction. Accumulating preclinical studies are providing an increasingly sound scientific basis for cautious human evaluation of additional gene and cell therapy strategies. Furthermo...
متن کاملTargeting adenovirus to the serotype 3 receptor increases gene transfer efficiency to ovarian cancer cells.
Gene delivery efficiency in clinical cancer gene therapy trials with recombinant adenoviruses (Ads) based on serotype 5 (Ad5) has been limited partly because of variable expression of the primary Ad5 receptor, the coxsackie and adenovirus receptor (CAR), on human primary cancer cells. As a means of circumventing CAR deficiency, Ad vectors have been retargeted by creating chimeric fibers possess...
متن کاملTargeting MicroRNAs in Prostate Cancer Radiotherapy
Radiotherapy is one of the most important treatment options for localized early-stage or advanced-stage prostate cancer (CaP). Radioresistance (relapse after radiotherapy) is a major challenge for the current radiotherapy. There is great interest in investigating mechanisms of radioresistance and developing novel treatment strategies to overcome radioresistance. MicroRNAs (miRNAs) are small, no...
متن کاملTargeting phospholamban by gene transfer in human heart failure.
BACKGROUND Myocardial cells from failing human hearts are characterized by abnormal calcium handling, a negative force-frequency relationship, and decreased sarcoplasmic reticulum Ca2+ ATPase (SERCA2a) activity. In this study, we tested whether contractile function can be improved by decreasing the inhibitory effects of phospholamban on SERCA2a with adenoviral gene transfer of antisense phospho...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biomedicine and Biotechnology
سال: 2003
ISSN: 1110-7243,1110-7251
DOI: 10.1155/s1110724303209062