Targeting Mitochondrial Bioenergetics for Alzheimers Prevention and Treatment
نویسندگان
چکیده
منابع مشابه
Mitochondrial Bioenergetics and ROS Production
immersed in a medium containing 21% oxygen, a highly reactive molecule. Fortunately for us, this impediment to life has been turned back on itself and has actually been harnessed by the cell to generate the stored chemical energy necessary to meet the major demands of cell physiology. Mitochondria are the organelles providing this protection, compartmentalizing and controlling the oxidation of ...
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AMP-activated protein kinase (AMPK) is an important mediator in maintaining cellular energy homeostasis. AMPK is activated in response to a shortage of energy. Once activated, AMPK can promote ATP production and regulate metabolic energy. AMPK is a known target for treating metabolic syndrome and type-2 diabetes; however, recently AMPK is emerging as a possible metabolic tumor suppressor and ta...
متن کاملMitochondrial DNA maintenance and bioenergetics.
Oxidative phosphorylation requires assembly of the protein products of both mitochondrial and of nuclear genomes into functional respiratory complexes. Cellular respiration can be compromised when mitochondrial DNA (mtDNA) sequences are corrupted. Oxidative damage resulting from reactive oxygen species (ROS) produced during respiration is probably a major source of mitochondrial genomic instabi...
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The major function of mitochondria is production and supply of cellular energy. Mitochondria are highly dynamic organelles undergoing frequent shape changes via fission and fusion. Many studies have elucidated the molecular components mediating fission and fusion and their regulatory mechanisms, and mitochondrial shape change is now recognized as an essential cellular process that is closely as...
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ژورنال
عنوان ژورنال: Current Pharmaceutical Design
سال: 2011
ISSN: 1381-6128
DOI: 10.2174/138161211798072517