Targeting low molecular weight cyclin E (LMW-E) in breast cancer
نویسندگان
چکیده
منابع مشابه
Cyclin E low-molecular-weight isoform as a predictor of breast cancer in Japanese women.
Overexpression of low-molecular-weight isoforms (LMWI) of cyclin E in breast cancer cells is associated with poor prognosis and could serve a novel role in breast cancer progression. LMWI originate from proteolytic processing of cyclin E, which is deregulated and hyperactive. In this study, levels of full-form/LMWI cyclin E were determined with the use of Western blot analysis in 69 Japanese br...
متن کاملCdk2 is required for breast cancer mediated by the low-molecular-weight isoform of cyclin E.
Cyclin E activates Cdk2, controls centrosome duplication, and regulates histone gene transcription. Cyclin E is deregulated in cancer and appears as low-molecular-weight (LMW) isoforms that correlate strongly with decreased survival in breast cancer patients. Transgenic mice overexpressing LMW-cyclin E have increased incidence of mammary tumors and distant metastasis when compared with mice tha...
متن کاملLow-molecular-weight cyclin E can bypass letrozole-induced G1 arrest in human breast cancer cells and tumors.
PURPOSE Low-molecular-weight cyclin E (LMW-E) in breast cancer cells induces genomic instability and resistance to inhibition by p21, p27, and fulvestrant therapy. Here, we sought to determine if LMW-E renders breast cancer cells unresponsive to aromatase inhibitors (AI), elucidate the mechanism of such resistance, and ascertain if inhibitors of LMW-E-associated kinase activity could overcome t...
متن کاملCyclin E Expression and Proliferation in Breast Cancer
Cyclin E is a part of the cell cycle machinery and aberrantly expressed in several malignancies including breast cancer. Since cyclin E is cell cycle specifically expressed, we wanted to examine the relation between proliferation and expression of cyclin E with special attention to tumours with overexpression of the protein. Seventy-four breast tumours were analysed for the expression of cyclin...
متن کاملLow molecular weight cyclin E overexpression shortens mitosis, leading to chromosome missegregation and centrosome amplification.
Overexpression of the low molecular weight isoforms (LMW-E) of cyclin E induces chromosome instability; however, the degree to which these tumor-specific forms cause genomic instability differs from that of full-length cyclin E (EL), and the underlying mechanism(s) has yet to be elucidated. Here, we show that EL and LMW-E overexpression impairs the G(2)-M transition differently and leads to dif...
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ژورنال
عنوان ژورنال: Breast Cancer Research and Treatment
سال: 2011
ISSN: 0167-6806,1573-7217
DOI: 10.1007/s10549-011-1638-4