Targeting human dendritic cell subsets for improved vaccines
نویسندگان
چکیده
منابع مشابه
Human dendritic cell subsets
Dendritic cells are highly adapted to their role of presenting antigen and directing immune responses. Developmental studies indicate that DCs originate independently from monocytes and tissue macrophages. Emerging evidence also suggests that distinct subsets of DCs have intrinsic differences that lead to functional specialisation in the generation of immunity. Comparative studies are now allow...
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Purpose: Anticancer dendritic cell (DC) vaccines require the DCs to relocate to lymph nodes (LN) to trigger immune responses.However, thesemigration rates are typically very poor. Improving the targeting of ex vivo generatedDCs to LNsmight increase vaccine efficacy and reduce costs.We investigatedDCmigration in vivo in humans under different conditions. Experimental Design:HLA-A 02:01 patients ...
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PURPOSE Anticancer dendritic cell (DC) vaccines require the DCs to relocate to lymph nodes (LN) to trigger immune responses. However, these migration rates are typically very poor. Improving the targeting of ex vivo generated DCs to LNs might increase vaccine efficacy and reduce costs. We investigated DC migration in vivo in humans under different conditions. EXPERIMENTAL DESIGN HLA-A*02:01 p...
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Dendritic cells (DCs) are key antigen-presenting cells for stimulating immune responses and they are now being investigated in clinical settings. Although defined as lineage-negative (Lin(-)) HLA-DR(+) cells, significant heterogeneity in these preparations is apparent, particularly in regard to the inclusion or exclusion of CD14(+), CD16(+), and CD2(+) cells. This study used flow cytometry and ...
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The mechanisms by which microbial vaccines interact with human APCs remain elusive. Herein, we describe the transcriptional programs induced in human DCs by pathogens, innate receptor ligands and vaccines. Exposure of DCs to influenza, Salmonella enterica and Staphylococcus aureus allows us to build a modular framework containing 204 transcript clusters. We use this framework to characterize th...
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ژورنال
عنوان ژورنال: Seminars in Immunology
سال: 2011
ISSN: 1044-5323
DOI: 10.1016/j.smim.2011.01.004