Targeting Eosinophils in Asthma
نویسندگان
چکیده
منابع مشابه
Expression of the Apoptosis Inhibitor Bcl-2 in Sputum Eosinophils in Patients with Asthma
Background and Objectives: Apoptosis of eosinophils is of significant value in assessing the airway inflammation in patients with asthma. Our purpose was to investigate the degree of expression of the Bcl-2 protein in sputum eosinophils during acute asthma exacerbation and its relationship with exacerbation severity. Materials and Methods: The study was carried out in Mostafa Khomeini Ho...
متن کاملEosinophils in asthma and other allergic diseases.
A hallmark of allergic disease is infiltration of the tissues with increased numbers of eosinophils. This is the result of the co-ordinated action of cytokines, particularly IL-5, CCR3 binding chemokines and the adhesion molecules P-selectin and VCAM-1, acting in concert to cause selective trafficking of eosinophils into allergic tissue. This process is orchestrated by the Th-2 allergen specifi...
متن کاملThe Role of Eosinophils in Asthma
Asthma is a common respiratory disease. The prevalence of asthma has been increasing over the past twenty years in most countries, and it affects up to 10% of the population of developed countries. Airway inflammation is a major factor in the pathogenesis of asthma. The presence of peripheral blood eosinophilia and activated eosinophils in the chronic inflammatory infiltrate of the airways is a...
متن کاملHistamines, basophils and eosinophils in severe asthma.
1. Arterial and venous whole blood and plasma histamine concentrations and eosinophil and basophil counts were determined in five patients with acute severe asthma who had not previously received steroid therapy, in five who had been maintained on steroid therapy and in a control group of nine patients with acute non-respiratory illnesses. 2. No significant arteriovenous differences were observ...
متن کاملExhaled nitric oxide correlates with airway eosinophils in childhood asthma.
BACKGROUND Exhaled nitric oxide has been proposed as a marker for airway inflammation in asthma. The aim of this study was to compare exhaled nitric oxide levels with inflammatory cells and mediators in bronchoalveolar lavage fluid from asthmatic and normal children. METHODS Children were recruited from elective surgical lists and a non-bronchoscopic bronchoalveolar lavage (BAL) was performed...
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ژورنال
عنوان ژورنال: Current Molecular Medicine
سال: 2008
ISSN: 1566-5240
DOI: 10.2174/156652408785748013