Targeting Drp1 and mitochondrial fission for therapeutic immune modulation
نویسندگان
چکیده
منابع مشابه
A role for septin 2 in Drp1‐mediated mitochondrial fission
Mitochondria are essential eukaryotic organelles often forming intricate networks. The overall network morphology is determined by mitochondrial fusion and fission. Among the multiple mechanisms that appear to regulate mitochondrial fission, the ER and actin have recently been shown to play an important role by mediating mitochondrial constriction and promoting the action of a key fission facto...
متن کاملA novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity.
Excessive mitochondrial fission is associated with the pathology of a number of neurodegenerative diseases. Therefore, inhibitors of aberrant mitochondrial fission could provide important research tools in addition to potential leads for drug development. Using a rational approach, we designed a novel and selective peptide inhibitor, P110, of excessive mitochondrial fission. P110 inhibits Drp1 ...
متن کاملThe mitochondrial fission factor Drp1 modulates T Cell Receptor signaling at the immune synapse
As you can see, the three referees find the analysis interesting, insightful and support publication the EMBO Journal, pending satisfactory revisions. Revisions are needed and in particular referees #2 and 3 raise a number of issues that have to be resolved in order for further consideration here. Should you be able to address the concerns raised then we would be happy to consider a revised ver...
متن کاملThe mitochondrial fission receptor Mff selectively recruits oligomerized Drp1
Dynamin-related protein 1 (Drp1) is the GTP-hydrolyzing mechanoenzyme that catalyzes mitochondrial fission in the cell. Residing in the cytosol as dimers and tetramers, Drp1 is recruited by receptors on the mitochondrial outer membrane, where it further assembles into a helical ring that drives division via GTP-dependent constriction. The Drp1 receptor Mff is a major regulator of mitochondrial ...
متن کاملMff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells
The cytoplasmic dynamin-related guanosine triphosphatase Drp1 is recruited to mitochondria and mediates mitochondrial fission. Although the mitochondrial outer membrane (MOM) protein Fis1 is thought to be a Drp1 receptor, this has not been confirmed. To analyze the mechanism of Drp1 recruitment, we manipulated the expression of mitochondrial fission and fusion proteins and demonstrated that (a)...
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ژورنال
عنوان ژورنال: Pharmacological Research
سال: 2019
ISSN: 1043-6618
DOI: 10.1016/j.phrs.2019.104317