Targeting Autophagy to Counteract Obesity-Associated Oxidative Stress

Reactive oxygen species (ROS) operate as key regulators of cellular homeostasis within a physiological range concentrations, yet they turn into cytotoxic entities when their levels exceed threshold limit. Accordingly, ROS are an important etiological cue for obesity, which in represents major risk factor multiple diseases, including diabetes, cardiovascular disorders, non-alcoholic fatty liver disease, and cancer. Therefore, the implementation novel therapeutic strategies to improve obese phenotype by targeting oxidative stress is great interest scientific community. To this end, it high importance shed light on mechanisms through cells curtail production or limit toxic effects, order harness them anti-obesity therapy. In review, we specifically discuss role autophagy redox biology, focusing its implication pathogenesis obesity. Because triggered response imbalance quintessential cytoprotective mechanism, maneuvers based activation hold promises efficacy prevention treatment obesity obesity-related morbidities.