منابع مشابه
Interaction Between Mitochondria and Caspases: Apoptotic and Non-Apoptotic Roles
Mitochondria, play an important role in a variety of processes including energy production, apoptosis, autophagy and inflammation. Caspases, are proteases that play an essential role in mediating apoptotic process of programmed cell death. An association between mitochondria and caspases is very well defined during apoptosis. Besides apoptosis, emerging data is strongly suggesting a direct asso...
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Apoptosis, a major form of programmed cell death, is an important mechanism to remove extra or unwanted cells during development. In tissue homeostasis apoptosis also acts as a monitoring machinery to eliminate damaged cells in response to environmental stresses. During these processes, caspases, a group of proteases, have been well defined as key drivers of cell death. However, a wealth of evi...
متن کاملBcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy.
Defects in apoptotic pathways can promote cancer cell survival and also confer resistance to antineoplastic drugs. One pathway being targeted for antineoplastic therapy is the anti-apoptotic B-cell lymphoma-2 (Bcl-2) family of proteins (Bcl-2, Bcl-XL, Bcl-w, Mcl-1, Bfl1/A-1, and Bcl-B) that bind to and inactivate BH3-domain pro-apoptotic proteins. Signals transmitted by cellular damage (includi...
متن کاملActivation of Pro-apoptotic Caspases in Non-apoptotic Cells During Odontogenesis and Related Osteogenesis
Caspases are well known proteases in the context of inflammation and apoptosis. Recently, novel roles of pro-apoptotic caspases have been reported, including findings related to the development of hard tissues. To further investigate these emerging functions of pro-apoptotic caspases, the in vivo localisation of key pro-apoptotic caspases (-3,-6,-7,-8, and -9) was assessed, concentrating on the...
متن کاملApoptotic signaling pathways: caspases and stress-activated protein kinases.
Apoptotic cell death is an active process mediated by various signaling pathways, which include the caspase cascade and the stress-activated protein kinase pathways. The caspase cascade is activated by two distinct routes: one from cell surface and the other from mitochondria. Activation of the route from cell surface requires the cellular components that include membrane receptors, adaptor pro...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
سال: 2020
ISSN: 0167-4889
DOI: 10.1016/j.bbamcr.2020.118688