Targeting and inactivation of bacterial toxins by human defensins
نویسندگان
چکیده
منابع مشابه
Human defensins facilitate local unfolding of thermodynamically unstable regions of bacterial protein toxins.
Defensins are short cationic, amphiphilic, cysteine-rich peptides that constitute the front-line immune defense against various pathogens. In addition to exerting direct antibacterial activities, defensins inactivate several classes of unrelated bacterial exotoxins. To date, no coherent mechanism has been proposed to explain defensins' enigmatic efficiency toward various toxins. In this study, ...
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ژورنال
عنوان ژورنال: Biological Chemistry
سال: 2017
ISSN: 1437-4315,1431-6730
DOI: 10.1515/hsz-2017-0106