Targeting adenoviral vectors using heterofunctional polyethylene glycol FGF2 conjugates

9 - Targeted Adenoviral Vectors I: Transductional Targeting

Physician Awareness of Immune Responses to Polyethylene Glycol‐Drug Conjugates

Antibodies against polyethylene glycol (PEG) can critically jeopardize the efficacy and safety of PEGylated therapeutics. For some PEG-drugs, a sizeable fraction of patients develop anti-PEG antibodies (APA), leading to reduced efficacy and potential adverse events. We surveyed physicians from several specialties to assess their awareness of APA. Overall, 83% of the physicians surveyed indicate...

Targeting adenoviral vectors for enhanced gene therapy of uterine leiomyomas.

STUDY QUESTION Is targeted adenovirus vector, Ad-SSTR-RGD-TK (Adenovirus -human somatostatin receptor subtype 2- arginine, glycine and aspartate-thymidine kinase), given in combination with ganciclovir (GCV) against immortalized human leiomyoma cells (HuLM) a potential therapy for uterine fibroids? SUMMARY ANSWER Ad-SSTR-RGD-TK/GCV, a targeted adenovirus, effectively reduces cell growth in Hu...

Using Multivalent Adenoviral Vectors for HIV Vaccination

Adenoviral vectors have been used for a variety of vaccine applications including cancer and infectious diseases. Traditionally, Ad-based vaccines are designed to express antigens through transgene expression of a given antigen. For effective vaccine development it is often necessary to express or present multiple antigens to the immune system to elicit an optimal vaccine as observed preclinica...

Fabrication of Clotrimazole microparticles using polyethylene glycol 6000 and beeswax

Backgrounds: Microparticles are one of drug delivery systems designed for sustained and controlled release of drugs for a long period of time. Clotrimazole is a broad-spectrum antifungal agent, which is generally used for treatment of Candida albicans and others fungal infections. Objectives: The present study aims to fabricate Clotrimazole microparticles using beeswax (lipophilic coating) an...