Targeted PI3K/AKT-hyperactivation induces cell death in chronic lymphocytic leukemia
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چکیده
منابع مشابه
Interleukin 10 induces apoptotic cell death of B-chronic lymphocytic leukemia cells
Recent studies have established that interleukin (IL)-10 induces growth and most notably differentiation of normal human B lymphocytes. We studied here the effects of IL-10 on the proliferation and survival of B-chronic lymphocytic leukemia (B-CLL) cells. IL-10 was found to inhibit 54-96% of the spontaneous tritiated thymidine incorporation observed in 3 of 12 B-CLL samples. Furthermore, IL-10 ...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2021
ISSN: 2041-1723
DOI: 10.1038/s41467-021-23752-2