Targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest: a statistical analysis plan
نویسندگان
چکیده
منابع مشابه
Detailed statistical analysis plan for the target temperature management after out-of-hospital cardiac arrest trial
BACKGROUND Animal experimental studies and previous randomized trials suggest an improvement in mortality and neurological function with temperature regulation to hypothermia after cardiac arrest. According to a systematic review, previous trials were small, had a risk of bias, evaluated select populations, and did not treat hyperthermia in the control groups. The optimal target temperature man...
متن کاملTherapeutic hypothermia after out-of-hospital cardiac arrest in children.
BACKGROUND Therapeutic hypothermia is recommended for comatose adults after witnessed out-of-hospital cardiac arrest, but data about this intervention in children are limited. METHODS We conducted this trial of two targeted temperature interventions at 38 children's hospitals involving children who remained unconscious after out-of-hospital cardiac arrest. Within 6 hours after the return of c...
متن کاملMild induced hypothermia after out-of-hospital cardiac arrest
Mild induced hypothermia after out-of-hospital cardiac arrest Niklas Nielsen, Hans Friberg, Christian Gluud , Johan Herlitz, Jørn Wetterslev Department of Clinical Sciences, Section of Anasthesia and Intensive Care, Lund University, Lund, Sweden Department of Anaesthesia and Intensive Care, Helsingborg Hospital, Helsingborg, Sweden Department of Emergency Medicine, Lund University Hospital, Lun...
متن کاملTargeted temperature management after out-of-hospital cardiac arrest: who, when, why, and how?
OBJECTIVE To provide a succinct review of the evidence, framed for the emergency department clinician, for the application of targeted temperature management (TTM) for patients after out-of-hospital cardiac arrest (OHCA). SOURCES OF INFORMATION MEDLINE, EMBASE, and the Cochrane database were searched for prospective and retrospective studies relevant to the indications of TTM, optimal timing ...
متن کاملTargeted temperature management after out-of-hospital cardiac arrest: certainties and uncertainties
Targeted temperature management was adopted as part of the treatment of unconscious survivors of out-ofhospital cardiac arrest following the publication of two landmark studies [1,2] which concluded that mild induced hypothermia (32°C to 34°C) improved survival and neurological outcome, substantiating the neuroprotective effect of mild hypothermia described in experimental animal data [3]. Subs...
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ژورنال
عنوان ژورنال: Trials
سال: 2020
ISSN: 1745-6215
DOI: 10.1186/s13063-020-04654-y