Targeted alpha therapy using astatine (211At)-labeled phenylalanine: A preclinical study in glioma bearing mice
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چکیده
منابع مشابه
Functionalized NaA nanozeolites labeled with 224,225Ra for targeted alpha therapy
The 223Ra, 224Ra, and 225Ra radioisotopes exhibit very attractive nuclear properties for application in radionuclide therapy. Unfortunately the lack of appropriate bifunctional ligand for radium is the reason why these radionuclides have not found application in receptor-targeted therapy. In the present work, the potential usefulness of the NaA nanozeolite as a carrier for radium radionuclides ...
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Background Glioma is the most aggressive and lethal brain tumor in humans, it comprises about 30 per cent of all brain tumors and central nervous system tumors. Purpose The objective of this study was to create novel brain-targeting nanoliposomes to encapsulate curcumin as a promising option for glioma therapy. Patients and methods Human glioma cells (U251MG) were used to determine cell upt...
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A “wet chemistry” approach for isolation of At from an irradiated bismuth target is described. The approach involves five steps: (1) dissolution of bismuth target in conc. HNO3; (2) removal of the HNO3 by distillation; (3) dissolution of residue in 8 M HCl; (4) extraction of At from 8 M HCl into DIPE; and (5) extraction of At from DIPE into NaOH. Results from 55 “optimized” At isolation runs ga...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2020
ISSN: 1949-2553
DOI: 10.18632/oncotarget.27552