Target Site Localization Dynamics of DNA-Binding Proteins in Vivo
نویسندگان
چکیده
منابع مشابه
Dynamic strategies for target-site search by DNA-binding proteins.
Gene regulatory proteins find their target sites on DNA remarkably quickly; the experimental binding rate for lac repressor is orders-of-magnitude higher than predicted by free diffusion alone. It has been proposed that nonspecific binding aids the search by allowing proteins to slide and hop along DNA. We develop a reaction-diffusion theory of protein translocation that accounts for transport ...
متن کاملBinding site identification in target proteins
Yi Xiong obtained his PhD degree in bioinformatics from Wuhan University, China, in 2011. He worked as a research assistant at the Department of Bioinformatics and Biostatistics in Shanghai Jiao Tong University, China, from 2009 to 2011. He is currently working as a postdoctoral research associate at the Department of Biological Sciences, Purdue University (IN, USA). He has published several sc...
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Knowledge-based models for protein folding assume that the early-stage structural form of a polypeptide is determined by the backbone conformation, followed by hydrophobic collapse. Side chain-side chain interactions, mostly of hydrophobic character, lead to the formation of the hydrophobic core, which seems to stabilize the structure of the protein in its natural environment. The fuzzy-oil-dro...
متن کاملSearch by proteins for their DNA target site: 2. The effect of DNA conformation on the dynamics of multidomain proteins
Multidomain transcription factors, which are especially abundant in eukaryotic genomes, are advantageous to accelerate the search kinetics for target site because they can follow the intersegment transfer via the monkey-bar mechanism in which the protein forms a bridged intermediate between two distant DNA regions. Monkey-bar dynamics highly depends on the properties of the multidomain protein ...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2011
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2010.12.582