Taperin (c9orf75), a mutated gene in nonsyndromic deafness, encodes a vertebrate specific, nuclear localized protein phosphatase one alpha (PP1α) docking protein
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چکیده
منابع مشابه
Taperin (c9orf75), a mutated gene in nonsyndromic deafness, encodes a vertebrate specific, nuclear localized protein phosphatase one alpha (PP1α) docking protein
The promiscuous activity of protein phosphatase one (PP1) is controlled in the cell by associated proteins termed regulatory or targeting subunits. Using biochemical and proteomic approaches we demonstrate that the autosomal recessive nonsyndromic hearing loss gene, taperin (C9orf75), encodes a protein that preferentially docks the alpha isoform of PP1. Taperin associates with PP1 through a cla...
متن کاملTaperin (c9orf75), a mutated gene in nonsyndromic deafness, encodes a vertebrate specific, nuclear localized protein phosphatase one alpha (PP1a) docking protein
Tony Ferrar*, Delphine Chamousset*, Veerle De Wever, Mhairi Nimick, Jens Andersen, Laura Trinkle-Mulcahy and Greg B. G. Moorhead Department of Biological Sciences, University of Calgary, 2500 University Dr, Calgary, Alberta, T2N 1N4, Canada Department of Cellular & Molecular Biology and Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON, Canada Department of Biochemistry & Mo...
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Targeted genome capture combined with next-generation sequencing was used to analyze 2.9 Mb of the DFNB79 interval on chromosome 9q34.3, which includes 108 candidate genes. Genomic DNA from an affected member of a consanguineous family segregating recessive, nonsyndromic hearing loss was used to make a library of fragments covering the DFNB79 linkage interval defined by genetic analyses of four...
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ژورنال
عنوان ژورنال: Biology Open
سال: 2011
ISSN: 2046-6390
DOI: 10.1242/bio.2011049