Tantangan dalam Menjaga Cerebral Perfusion Pressure (CPP) yang Aman pada Cedera Otak Traumatik

Cerebral perfusion pressure (CPP) is the net gradient that drives oxygen delivery to cerebral tissue. It difference between mean arterial (MAP) and intracranial (ICP), CPP = MAP-CVP or =MAP – ICP if ICP>CVP. must be maintained within narrow limits because too litle could cause brain tissue become ischemic, much raise pressure. The normal range lies 60 80 mmHg, but these values can shift left right depending on individual patient physiology. As a calculated measure, MAP measured simultaneously, most commonly by invasive means. When injury occurs, capillaries “leaky” more permeable water. In addition, blood vessels may dilate in respons injury, hypoxemia, hypercarbia, acidosis, hypotension. If becomes elevated, increased lead flow. recommended goal of per Brain Trauma Foundation (BTF) guideline 50-70 mmHg. Targeting high >70 mmHg has not been shown beneficial with traumatic associated an risk acute respiratory distress syndrome (ARDS).