Tamoxifen and tranilast show a synergistic effect against breast cancer in vitro
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چکیده
منابع مشابه
The Effects of Tamoxifen in Combination with Tranilast on CXCL12- CXCR4 Axis and Invasion in Breast Cancer Cell Lines
It has been reported that CXCL12 binding to CXCR4 induces several intracellular signaling pathways, and enhances survival, proliferation, and migration of malignant cells. Herein we examined the effects of anti-estrogen tamoxifen and anti-allergic tranilast drugs as a single or in combination on invasion by two in vitro invasion assays, wound-healing and matrigel invasion on MCF-7 and MDA-MB-23...
متن کاملThe Effects of Tamoxifen in Combination with Tranilast on CXCL12- CXCR4 Axis and Invasion in Breast Cancer Cell Lines
It has been reported that CXCL12 binding to CXCR4 induces several intracellular signaling pathways, and enhances survival, proliferation, and migration of malignant cells. Herein we examined the effects of anti-estrogen tamoxifen and anti-allergic tranilast drugs as a single or in combination on invasion by two in vitro invasion assays, wound-healing and matrigel invasion on MCF-7 and MDA-MB-23...
متن کاملSynergistic Effects of Tamoxifen and Tranilast on VEGF and MMP-9 Regulation in Human Breast Cancer Cells
Tumor angiogenesis, the formation of new blood capillaries from preexisting blood vessels (Bergers and Benjamin, 2003), supports growth and development of the tumor mass and is an essential process during growth and progression of breast cancer (Banerjee et al., 2007). Vascular endothelial growth factor (VEGF) is the most well-known pro-angiogenic growth factor, and thought to be the most criti...
متن کاملthe effects of tamoxifen in combination with tranilast on cxcl12- cxcr4 axis and invasion in breast cancer cell lines
it has been reported that cxcl12 binding to cxcr4 induces several intracellular signaling pathways, and enhances survival, proliferation, and migration of malignant cells. herein we examined the effects of anti-estrogen tamoxifen and anti-allergic tranilast drugs as a single or in combination on invasion by two in vitro invasion assays, wound-healing and matrigel invasion on mcf-7 and mda-mb-23...
متن کاملThe Effects of Tamoxifen in Combination with Tranilast on CXCL12-CXCR4 Axis and Invasion in Breast Cancer Cell Lines
It has been reported that CXCL12 binding to CXCR4 induces several intracellular signaling pathways, and enhances survival, proliferation, and migration of malignant cells. In the present study, we examined the effects of anti-estrogen tamoxifen and anti-allergic tranilast drugs as a single or in combination on invasion by two in-vitro invasion assays, wound-healing and matrigel invasion on MCF-...
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ژورنال
عنوان ژورنال: Bratislava Medical Journal
سال: 2015
ISSN: 1336-0345
DOI: 10.4149/bll_2015_013