منابع مشابه
DNA Loci Cross-Talk through Thermodynamics
The recognition and pairing of specific DNA loci, though crucial for a plenty of important cellular processes, are produced by still mysterious physical mechanisms. We propose the first quantitative model from Statistical Mechanics, able to clarify the interaction allowing such "DNA cross-talk" events. Soluble molecules, which bind some DNA recognition sequences, produce an effective attraction...
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Myh1 is a DNA glycosylase that is involved in base excision repair after oxidation damage. It excises mis-incorporated adenine opposite to the lesion 8-oxoG. The human homolog MUTYH, is important in tumour development as mutations in the MUTYH lead to G: C to T: A transversion mutations in MUTYH hereditary colon cancer. Pst2 (Sin3 homolog) is a scaffold protein and forms a complex with Clr6 His...
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Tyrosine kinases respond to extracellular and intracellular cues by activating specific cellular signaling cascades to regulate cell cycle, growth, proliferation, differentiation and survival. Likewise, DNA damage response proteins (DDR) activated by DNA lesions or chromatin alterations recruit the DNA repair and cell cycle checkpoint machinery to restore genome integrity and cellular homeostas...
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ژورنال
عنوان ژورنال: Nature
سال: 1983
ISSN: 0028-0836,1476-4687
DOI: 10.1038/302776a0