Tacrolimus for treatment of toxic epidermal necrolysis
نویسندگان
چکیده
منابع مشابه
[Toxic epidermal necrolysis].
Toxic epidermal necrolysis is a potentially fatal dermatological disease. Large bullae covering extensive areas of the body cause continuous exfoliation of skin, which requires immediate medical attention. Intraoral manifestations may precede cutaneous lesions. Two cases with different treatment protocols are presented.
متن کاملToxic Epidermal Necrolysis
Figure 1. Generalized epidermolysis on anterior and posterior torso with crusty erosions on oral mucosa. DESCRIPTION A 33-year-old woman presents with diffuse rash 3 weeks after completing a course of Bactrim for a urinary tract infection. Erythematous maculopapular rash is evident on the trunk and extremities with painful, epidermal sloughing on the back leaving a moist, denuded dermis. Note t...
متن کاملIntrapartum Toxic Epidermal Necrolysis.
This syndrome was first described by Lyell (1956) in this country and by Lang and Walker (1956) in South Africa and has since been reported with increasing frequency. Beare (1962), in a comprehensive review, collected 35 cases from the published reports and described 10 further cases that he had observed personally. He suggests that it is unlikely that the syndrome could have been seen in the U...
متن کاملReview of Toxic Epidermal Necrolysis
Toxic epidermal necrolysis (TEN) is a rare but life threatening mucocutaneous reaction to drugs or their metabolites. It is characterised by widespread keratinocyte apoptosis and sloughing of the skin, erosions of the mucous membranes, painful blistering, and severe systemic disturbance. The pathophysiology of TEN is incompletely understood. Historically, it has been regarded as a drug-induced ...
متن کاملEpidermal necrolysis (StevenseJohnson syndrome and toxic epidermal necrolysis): Historical considerations
Objective: To describe the history of toxic epidermal necrolysis, before and after the original report by the British dermatologist Alan Lyell in 1956. Methods: Subjective expert choice of key advances in the comprehension of the nosology, classification, causality, and mechanisms of epidermal necrolysis (EN) over more than a century. Results: Epidermolysis had been reported long before Lyell’s...
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ژورنال
عنوان ژورنال: Indian Journal of Dermatology, Venereology, and Leprology
سال: 2015
ISSN: 0378-6323
DOI: 10.4103/0378-6323.168328