Tacrolimus-associated sinus obstruction syndrome after liver transplantation from a living related donor
نویسندگان
چکیده
Sinusoidal obstruction syndrome (SOS), previously known as hepatic veno-occlusive disease, is manifested by obliterating inflammation of the terminal veins, characterized hepatomegaly, right upper quadrant pain, jaundice and ascites, most often occurs in patients after hematopoietic stem cell transplantation usually those who received platinum drugs. Cases SOS development solid organs (lungs, pancreas, liver) are also recorded world literature. rare, liver lobe from a living family donor - isolated poorly studied. The diagnosis established on basis clinical signs, imaging techniques (according to ultrasound radiological research methods), histological study biopsy. Tacrolimus has been reported be causative agent that potentially plays role pathophysiological mechanism SOS. Purpose relationship between prolonged-release tacrolimus sinusoidal transplantation. Clinical case. In this article, we present case transplantation, which was associated with toxic effect («Envarsus»). 55-year-old man, high concentrations blood uncontrolled drug intake were recorded. When carrying out number laboratory instrumental methods connection appearance massive established. After excluding other possible contributing factors, including an acute rejection crisis, it concluded long-acting («Envarsus») cause carried accordance principles Helsinki Declaration. informed consent patient obtained for conducting studies. No conflict interests declared authors.
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ژورنال
عنوان ژورنال: ???????? ???????? ????
سال: 2023
ISSN: ['2521-1358', '2304-0041']
DOI: https://doi.org/10.15574/ps.2023.79.99