T regulatory lymphocytes and FoxP3 nuclear translocation in various adipose tissue depots in patients with coronary artery disease

T regulatory lymphocytes (Treg) are present is adipose tissue. Their frequency, as well the level of FoxP3 nuclear translocation, in epicardial and thymus tissue remains unexplored. Properties adiposeresident Tregs may be high significance patients with coronary artery disease potential pathophysiological factor development atherosclerosis. The aim study was to compare frequency + translocation epicardial, thymus, subcutaneous peripheral blood disease. A pilot conducted 11 scheduled for bypass graft surgery after prior selective angiography. Frequency CD4 CD25 hi lo were evaluated by imaging flow cytometry stromal vascular fraction Frequencies higher compared (3 5 times higher, p = 0.020); cells 4 than (p 0.028). highest decreased 0.020 both lymphocytes). directly related age (r s 0.818; 0.002), inversely -0.618; 0.043). negatively correlated -0.827; 0.002 r -0.648; 0.031, respectively). waist-to-hip ratio -0.700; 0.016). severity atherosclerosis only -0.655; 0.029). Thus, enriched Tregs, but factors that influence Treg accumulation these fat depots different. obtained results further used personalized immunomodulatory therapy