T cell specific and non specific tolerance mechanisms in peanut oil immunotherapy in peanut allergic subjects
نویسندگان
چکیده
منابع مشابه
T cell specific and non specific tolerance mechanisms in peanut oil immunotherapy in peanut allergic subjects
Rationale Our main focus in the laboratory is to understanding the mechanisms of how oral immunotherapy (OIT) improves outcomes in patients. In this study, we aimed to determine if OIT is specific only to the food allergens administered in OIT or also to other offending allergens (i.e. “bystander effect”). To accomplish our aim, we studied T cell reactivity (i.e. proliferation assays) and T cel...
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BACKGROUND Peanut allergy is the leading cause of food-related anaphylaxis, and accidental exposures are common. Oral immunotherapy (OIT) has been posited as a potential treatment. METHODS Patients aged 3-65 years with peanut-specific IgE ≥7 kU/l and/or a positive skin prick test with a history of an allergic reaction to peanut were recruited to undergo an OIT protocol. All adverse reactions ...
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Emerging data suggest that measurement of serum IgE to peanut components can be clinically helpful and more accurate than IgE to whole peanut to predict peanut allergy. Not all studies have used prospective samples, multiple components and oral challenges. Currently, there are no data on this topic involving Italian children. 32 patients (23 males; median age 9 years) with reported history for ...
متن کاملT-cell regulatory mechanisms in specific immunotherapy.
Allergen-specific immunotherapy (SIT) is the only treatment which leads to a lifelong tolerance against previously disease-causing allergens due to restoration of normal immunity against allergens. The description of T-regulatory (Treg) cells being involved in prevention of sensitization to allergens has led to great interest whether they represent a major target for allergen-SIT and whether it...
متن کاملPeanut immunotherapy
Peanut allergy is common and can be a cause of severe, life-threatening reactions. It is rarely outgrown like other food allergies, such as egg and milk. Peanut allergy has a significant effect on the quality of life of sufferers and their families, due to dietary and social restrictions, but mainly stemming from fear of accidental peanut ingestion. The current management consists of strict avo...
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ژورنال
عنوان ژورنال: Clinical and Translational Allergy
سال: 2011
ISSN: 2045-7022
DOI: 10.1186/2045-7022-1-s1-o34